HealthCare

Levocetirizine dihydrochloride - brand name Xyzal is a selective, long  acting peripheral H1   receptor antagonist antihistamine. The   increased polarity of Levocetirizin may decrease distribution of the drug into the CNS, resulting in reduced potential for adverse CNS effects. Drug tolerance does not occur as it does not readily cross the blood brain barrier. It does not cause sedation or interfere with mental alertness or memory function.  Levocetirizine dihydrochloride - Xyzal works by blocking the histamine receptors. While it may not stop  the actual release of histamines from mast cells it does prevents the binding of these histamines to its receptors. This effectively prevents the release of other allergy chemicals and increased blood supply to the area (ie) it prevents swelling and inflammation in the area. Thus it very effectively provides relief from the typical symptoms of hayfever and rhinitis.

Levocetirizine dihydrochloride - molecule was developed by UCB a multi national biopharmaceutical manufacturer headquartered in Brussels, Belgium. It is  available under the brand name Xyzal in the UK, Ireland, Austria, France, The Netherlands and Romania,. It is available as  Xuzal in Mexico and in Germany and Xozal in Greece. In Unites States Aventis - Sanofi has the permission to market Levocetirizine dihydrochloride under the brand name Xyzal.
Levocetirizine dihydrochloride Xyzal is used in the treatment of seasonal allergic rhinitis, perennial allergic rhinitis,ocular   symptom  like redness, lacrimation and itching. It is also indicated in the treatment of chronic idiopathic urticaria, urticaria dermographism, atopic eczema &contact dermatitis, also in acute allergic reactions due to drugs, food and insect bites.

Dosage: For adults and childern above 6 years  : Levocetirizine dihydrochloride  - Xyzal is given 5 mg as a single intake orally. For elderly  dosage is adjusted  on the basis of  renal function. 

Side Effctes of Xyzal. : Levocetirizine dihydrochloride Xyzal has to be used with caution during Pregnancy and during lactation it is secreted in breast milk. Contraindications Xyzal include severe renal impairment. Special precautions has to be taken by patients  intending to drive/ operate   machinery  or  engage   in   potentially hazardous activities should be warned not to take more than the recommended dose. Concurrent use with alcohol or other CNS depressant may cause reduction in alertness and impairment of performance. Although well tolerated some effects are headache, somnolence,  dry mouth,  mild drowsiness and G.I. disturbances. Drug Interactions: Rate of absorption is reduced with food.  Alcohol and CNS depressants may potentiate CNS side effects in sensitive patients.