visual and spatial information may be damaged in people with Alzheimer’s Disease
Tuesday, August 19th, 2008New research, however, has shown that a part of the brain that processes visual and spatial information may be damaged in people with Alzheimer’s Disease. Other parts of the brain including the basal forebrain and hippocampus, areas important for memory, are also affected by Alzheimer’s Disease. Research suggests that the formation of tangles in the brain may be a part of the normal aging process. Other observed changes in the brain affected by Alzheimer’s Disease include:. Neuronal degeneration in a part of the brain called the nucleus basalis of Meynert. Decreased brain levels of the neurotransmitter acetylcholine. Aprotein named tau has been shown to be involved informing NFTs, but more research is needed to solve the mystery of how and why NFTs form, and how exactly they affect the brain. The amyloid protein occurs naturally incur brains, but as we age, too much of it (in a form called beta amyloid)accumulates in the brain, forming plaques
Brain imaging methods can also be used to gain information about blood flow and metabolic activity in various parts of the brain. Brain imaging — Internal images of the brain help detect strokes, tumors or other conditions that may have affected the brain. Brain images can show changes to structures in the brain that are associated with memory, such as the hippocampus. Brain imaging techniques offered at Mayo Clinic are: Computed tomography (CT scan) — In this test, an X-ray machine rapidly rotates around the brain while taking a series of thin X-ray beams that produce two-dimensional images. Expanding Diagnostic Tools because a definitive diagnosis of Alzheimer’s Disease can only be made by examining the brain after a person dies, AD diagnosis in the living must be made by exclusion.
As imaging technology becomes more sophisticated and accessible, health professionals can use CAT scans to visualize brain shrinkage. As you age, some connections in your brain may fail due to tangles or plaques, so it makes sense that the more neural connections you have overall, the more you will be able to compensate for the damaged connections. Experiments on rats have shown that NGF promoted growth of new synaptic connections in a part of the brain called the hippocampus. Neurotransmitter Deficiencies in the Brain Neuronsuse neurotransmitters to communicate. As mentioned previously, acetylcholine levels are lower in Alzheimer’s Disease brains compared to non- Alzheimer’s Disease brains. Thus, drugs which promote increased levels of acetylcholine in the brain may slow the dementia. Scientists hypothesize that if your immune system attacks your brain as you age, Alzheimer’s Disease symptoms could result. However, it is unclear whether this leads to AD, because signs of this type of attack have been seen in non-AD brains.