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Excess presence of glucose in blood causes accelerated aging and degenerative diseases. These excess circulating glucose mole¬cules attach to the proteins molecules in the blood. This biochemical reaction is called as protein glycation. This process a sticky substance called "advanced glycosylation endproducts" or AGEs. AGEs accumulate in the blood and stick to organs and tissues while accelerating free-radical production. As a result, these organs and tissues suffer major damage. In the skin, AGEs cause wrinkling; in the brain, AGEs play a role in the development of Alzheimer's, Parkinson’s and other forms of mental impairment. The presence of protein plaques in brain is the mark of Alzheimer’s disease.

Diabetes causes risk of premature aging since diabetics have higher glucose levels in their blood leading to high degree glycosylation –protein plaques formation. Diabetics have high degree of neurological degen¬eration, kidney problems, and heart disease at much younger age while non-diabetic population faces this problem much later in life.
 
Furthermore, protein plaques play a major role in heart disease, by directly binding to LDL cholesterol and by stimulating the production of free radicals, which oxidize LDL cholesterol in the bloodstream. This initiates the formation of artery-clogging plaque deposits, leading to hardening of arteries and contributing to high blood pressure.18 In general, AGEs and free-radical production cause tissue damage, reduce organ capac¬ity, and accelerate biological aging. AGEs have been found to play a role in kidney and pancreat¬ic dysfunction, gastrointestinal inflammation, dia¬betes, arthritis, and cancer.

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