Donepezil- trade name Aricept cholinesterase inhibitor
An acetylcholinesterase inhibitor or anti-cholinesterase is a chemical that inhibits the cholinesterase enzyme from breaking down acetylcholine, so increasing both the level and duration of action of the neurotransmitter acetylcholine.
Donepezil- trade name Aricept is a centrally acting reversible acetyl cholinesterase inhibitor. It is used in the treatment of Alzheimer’s disease where it is used to increase cortical acetylcholine. Currently, there is no conclusive proof that donepezil halts/decreases the progression of Alzheimer’s disease. However many controlled studies have shown modest benefits in cognition and behavior. Many neurologists, psychiatrists, and primary care physicians use donepezil in patients with severe Alzheimer’s disease. But there is no significant improvement in functional outcome, of quality of life or of behavioral symptoms in those with mild to moderate Alzheimer’s disease. Donepezil comes as a tablet and dissolves quickly in the mouth. It is usually taken once a day, in the evening with or without food. The medicine is taken around the same time every day. It may take several weeks before the full benefits of donepezil are experienced . This drug helps control the symptoms of Alzheimer’s disease but does not cure it. It has to be taken even if the patients feels well and not stopped without talking to doctor.
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Tags: Aricept, cholinesterase, cholinesterase inhibitor, Donepezil