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The long-acting beta-adrenergic agonists are very effective in the management of asthma . Most often, beta-adreneigic agonists are inhaled using metered-dose inhalers (handheld cartridges containing gas under pressure}. The pressure pumps the drug into a fine spray containing a measured dose of drug. Inhalation deposits the drug directly in the airways, so that it acts quickly, but the drug may not reach the airways that arc severely obstructed. For people who have difficulty using a metered-dose inhaler, spacers or holding chambers can be used. With any type of inhaler, proper technique is vital; if the device is not used properly, the drug will not reach the airways. A dry powder drug formulation is also available. The powder formulation is easier for some people to use, in part because it requires less coordination with breathing. Beta-adrenergic agonists can also be delivered directly to the lungs by using a nebulizer. A nebulizer creates a mist of drug, and its use does not have to be coordinated with breathing. Nebulizers arc more portable than they were in the past; some units can even be plugged into a cigarette lighter in a car. Beta-adrenergic agonists can also be taken in liquid or tablet form or injected. However, the oral drugs tend to work slower than the inhaled or injected ones and are more likely to cause side effects. Side effects include abnormal heart rhythms, which may suggest excessive use. Other bronchodilators may be combined with beta-adrenergic agonists for acute attacks, including intravenous infusions of aminophylline (a type of theophylline) and nebulized ipratropium. Overusing these drugs can be very dangerous. The need for continuous use indicates severe bronchoconstriction, which can lead to respiratory failure and death. There are currently around 26 Popular beta-adreneigic agonists molecules in the market. They are : Amibegron, Arformoterol, Bambuterol,Bitolterol, Bromoacetylalprenololmenthane, Carbuterol, Clenbuterol, Dopexamine, ormoterol, Hexoprenaline, Indacaterol,Levosalbutamol, Orciprenaline, Pirbuterol, Procaterol, Ractopamine, Reproterol, Rimiterol, Salbutamol, Salmeterol, Solabegron, Terbutaline and Tulobuterols.
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{ 2008 08 23 }
